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Article

Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression.

Biochemical and biophysical research communications - 23 Nov 2007

Shi K, Ugi S, Shimizu S, Sekine O, Ikeda K, Egawa K, Yoshizaki T, Nagai Y, Nishio Y, Takada T, Torii R, Kimura H, Kashiwagi A, Maegawa H

Abstract excerpt

Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor in stimulating lipogenesis in the liver. Protein-tyrosine phosphatase 1B (PTP1B) induces SREBP-1 gene expression via protein phosphatase 2A (PP2A) activation. PTP1B is reported to be anchored on the endoplasmic re...

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Identifiers

PMID: 17897622
DOI: 10.1016/j.bbrc.2007.09.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17897622-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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