Article
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.
The Biochemical journal - 15 Mar 2000
Leslie N R, Gray A, Pass I, Orchiston E A, Downes C P
Abstract excerpt
The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides, Shc, focal adhesion kinase and phosphoinositide substrates. In cellular assays, PTEN has been shown to antagonize the PI-3K-depend...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.