Article
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling.
Current biology : CB - 1 May 1994
Wennström S, Hawkins P, Cooke F, Hara K, Yonezawa K, Kasuga M, Jackson T, Claesson-Welsh L, Stephens L
Abstract excerpt
BACKGROUND: There is substantial evidence that phosphoinositide 3-kinase (PI 3-kinase) is a critical component of signalling pathways used by the cell-surface receptors for a variety of mammalian growth factors and other hormones. The physiological product of this enzyme is a highly polar membrane lipid called phosphatidylinositol (3,4,5)-trisphosphate This lipid has been postulated to act as a second-messenger...
Topics
- Androstadienes
- Animals
- Binding Sites
- Cell Line
- Cell Membrane
- Enzyme Activation
- Models, Biological
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphorylation