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Article

Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains.

The Journal of biological chemistry - 31 Oct 2003

Zhao Runxiang, Fu Xueqi, Teng Lirong, Li Qingshan, Zhao Zhizhuang Joe

Abstract excerpt

SHP-2 is an Src homology 2 (SH2) domain-containing tyrosine phosphatase with crucial functions in cell signaling and major pathological implications. It stays inactive in the cytosol and is activated by binding through its SH2 domains to tyrosine-phosphorylated receptors on the cell surface. One...

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PMID: 12913007
DOI: 10.1074/jbc.M306136200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12913007-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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