Article
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion.
The Journal of biological chemistry - 14 Aug 1998
Yu D H, Qu C K, Henegariu O, Lu X, Feng G S
Abstract excerpt
Shp-2, a widely expressed cytoplasmic tyrosine phosphatase with two SH2 domains, is believed to participate in signal relay downstream of growth factor receptors. We show here that this phosphatase also plays an important role in the control of cell spreading, migration, and cytoskeletal architec...
Topics
- Animals
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- Cell Movement
- Cytoskeletal Proteins
- Fibroblasts
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Heterozygote
- Homozygote
- Intracellular Signaling Peptides and Proteins
- Mice
- Paxillin
- Phenotype
- Phosphoproteins
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6