Article
PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase.
FEBS letters - 18 Sept 1995
Chiarugi P, Cirri P, Raugei G, Camici G, Dolfi F, Berti A, Ramponi G
Abstract excerpt
Low M(r) phosphotyrosine protein phosphatase (LMW-PTP) is a 18 kDa cytosolic enzyme widely distributed in eukaryotic cells. LMW-PTP catalyses the hydrolysis of phosphotyrosine residues and overexpression of the enzyme in normal and transformed cells inhibits cell proliferation. Site directed mutagenesis, together with crystallographic studies, have contributed to clarify the catalytic mechanism, which involves...
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