Article
PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase.
FEBS letters - 18 Sept 1995
Chiarugi P, Cirri P, Raugei G, Camici G, Dolfi F, Berti A, Ramponi G
Abstract excerpt
Low M(r) phosphotyrosine protein phosphatase (LMW-PTP) is a 18 kDa cytosolic enzyme widely distributed in eukaryotic cells. LMW-PTP catalyses the hydrolysis of phosphotyrosine residues and overexpression of the enzyme in normal and transformed cells inhibits cell proliferation. Site directed muta...
Topics
- 3T3 Cells
- Animals
- Cell Division
- DNA
- Epidermal Growth Factor
- Insulin
- Mice
- Molecular Weight
- Phenotype
- Phosphorylation
- Platelet-Derived Growth Factor
- Point Mutation
- Protein Tyrosine Phosphatases