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Article

The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts.

Oncogene - 7 Dec 1995

Conzen S D, Cole C N

Abstract excerpt

Simian virus 40 (SV40) is a small DNA tumor virus whose early region gene product, large T antigen, is sufficient to immortalize primary rodent cells and transform established rodent cell lines. Three functional domains of large T antigen are required for transformation of the rat embryo fibroblast REF 52 cell line: the extreme amino-terminal region, a domain which binds p105Rb family members, and the bipartite...

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PMID: 8570180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts.PMID 8570180Read ↗

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Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts.Semantic proximity Read ↗

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