Article

Modeling wild type and mutant p53 in telomerase-immortalized human cells

2023-06-25

Abstract excerpt

Genetic alterations that change the functions of p53 or other proteins in the p53 pathway contribute to a majority of cancers. Accordingly, many technological approaches and model systems have been employed to dissect the complex phenotypes of this critical tumor suppressor and its mutants. Studies of human p53 are commonly conducted in tumor-derived cell lines that retain wild type TP53 alleles and isogenic deri...

Identifiers and source

Literature Corpus work: 7e8a3ddf-c757-5b36-9fbe-3c0b60d0211e
DOI: 10.1101/2023.06.22.546141

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