Article
Mutant p53-induced immortalization of primary human mammary epithelial cells.
Cancer research - 1 Jul 1996
Gao Q, Hauser S H, Liu X L, Wazer D E, Madoc-Jones H, Band V
Abstract excerpt
Mutations of the p53 gene are the most frequent genetic lesions in breast cancer, suggesting a critical role for p53 protein in normal mammary cell growth control. Indeed, the p53-targeting human papillomavirus oncogene E6 induces efficient immortalization of normal human mammary epithelial cells...
Topics
- Breast
- Breast Neoplasms
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Epithelial Cells
- Epithelium
- Female
- G1 Phase
- Gene Deletion
- Gene Expression
- Genes, p53
- Humans
- Mutation
- Nuclear Proteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2