Article
Mutant p53-induced immortalization of primary human mammary epithelial cells.
Cancer research - 1 Jul 1996
Gao Q, Hauser S H, Liu X L, Wazer D E, Madoc-Jones H, Band V
Abstract excerpt
Mutations of the p53 gene are the most frequent genetic lesions in breast cancer, suggesting a critical role for p53 protein in normal mammary cell growth control. Indeed, the p53-targeting human papillomavirus oncogene E6 induces efficient immortalization of normal human mammary epithelial cells (MECs). To assess whether selective loss of p53 is sufficient for MEC immortalization, we introduced seven missense...
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