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Article

SV40-lnduced Immortalization of Human Cells

1 Jan 1994

Abstract excerpt

For several decades simian virus 40 (SV40) early region genes have been used as a means of generating immortalized human cell lines; however, the molecular mechanisms of this process have begun to be understood only recently. SV40-induced immortalization proceeds via two phases. In the first phase ("lifespan extension"), cells continue proliferating for a limited number of population doublings beyond the point at...

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PMID: 7711112
DOI: 10.1615/critrevoncog.v5.i4.10

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