Article
The inward rectification mechanism of the HERG cardiac potassium channel.
Nature - 29 Feb 1996
Smith P L, Baukrowitz T, Yellen G
Abstract excerpt
A human genetic defect associated with 'long Q-T syndrome', an abnormality of cardiac rhythm involving the repolarization of the action potential, was recently found to lie in the HERG gene, which codes for a potassium channel. The HERG K+ channel is unusual in that it seems to have the architectural plan of the depolarization-activated K+ channel family (six putative transmembrane segments), yet it exhibits...
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