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Article

Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation.

Circulation research - 24 Aug 1998

Nakajima T, Furukawa T, Tanaka T, Katayama Y, Nagai R, Nakamura Y, Hiraoka M

Abstract excerpt

In a Xenopus oocyte heterologous expression system, we characterized the electrophysiology of 3 novel missense mutations of HERG identified in Japanese LQT2 families: T474I (within the S2-S3 linker), A614V, and V630L (in the outer mouth of pore-forming region). For each of the 3 mutations, injection of mutant cRNA alone did not express detectable currents. Coinjection of wild-type (WT) along with each mutant cRNA...

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Identifiers

PMID: 9721698
DOI: 10.1161/01.res.83.4.415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation.PMID 9721698Read ↗

Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2Semantic proximity Read ↗

Electrophysiological study of V535M hERG mutation of LQT2.Semantic proximity Read ↗

Characterization of S818L mutation in HERG C-terminus in LQT2. Modification of activation-deactivation gating properties.Semantic proximity Read ↗

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant.Semantic proximity Read ↗

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.Semantic proximity Read ↗

A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.Semantic proximity Read ↗

The inward rectification mechanism of the HERG cardiac potassium channel.Semantic proximity Read ↗

The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT.Semantic proximity Read ↗

An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.Semantic proximity Read ↗

A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2.Semantic proximity Read ↗

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.Semantic proximity Read ↗

Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations.Semantic proximity Read ↗

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