Article
Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation.
Circulation research - 24 Aug 1998
Nakajima T, Furukawa T, Tanaka T, Katayama Y, Nagai R, Nakamura Y, Hiraoka M
Abstract excerpt
In a Xenopus oocyte heterologous expression system, we characterized the electrophysiology of 3 novel missense mutations of HERG identified in Japanese LQT2 families: T474I (within the S2-S3 linker), A614V, and V630L (in the outer mouth of pore-forming region). For each of the 3 mutations, inject...
Topics
- Animals
- Cation Transport Proteins
- DNA Mutational Analysis
- DNA-Binding Proteins
- ERG1 Potassium Channel
- Electrocardiography
- Ether-A-Go-Go Potassium Channels
- Humans
- Long QT Syndrome
- Mutation
- Oocytes
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Trans-Activators
- Transcriptional Regulator ERG
- Xenopus laevis