Article
Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.
The Journal of physiology - 15 Jun 1996
Schönherr R, Heinemann S H
Abstract excerpt
1. The human eag-related potassium channel, HERG, gives rise to inwardly rectifying K+ currents when expressed in Xenopus oocytes. 2. The apparent inward rectification is caused by rapid inactivation. In extracellular Cs+ solutions, large outward currents can be recorded having an inactivation ti...
Topics
- Alanine
- Animals
- Biotransformation
- Humans
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Polymerase Chain Reaction
- Potassium Channels
- Sequence Deletion
- Serine
- Xenopus laevis