Na+ permeation and block of hERG potassium channels.

Abstract excerpt

The inactivation gating of hERG channels is important for the channel function and drug-channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation. By using whole cell patch clamp method with an internal solution containing 135 mM Na+...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ether-A-Go-Go Potassium Channels
• Share to Ion Channel Gating
• Share to Membrane Potentials