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Article

CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.

Molecular cell - 1 Jan 2000

Noton E, Diffley J F

Abstract excerpt

Passage through mitosis is required to reset replication origins for the subsequent S phase. During mitosis, a series of biochemical reactions involving cyclin-dependent kinases (CDKs), the anaphase promoting complex or cyclosome (APC/C), and a mitotic exit network including Cdc5, 14, and 15 coordinates the proper separation and segregation of sister chromatids. Here we show that cyclin B/CDK inactivation can...

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PMID: 10678171
DOI: 10.1016/s1097-2765(00)80405-0

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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