The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

doi:10.1242/jcs.111.6.843

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

Journal of cell science - 1 Mar 1998

Sánchez-Díaz A, González I, Arellano M, Moreno S

Abstract excerpt

p25rum1 and p40SIC1 are specific inhibitors of p34(cdc2/CDC28) kinase complexes with B-type cyclins that play a central role in the regulation of the G1 phase of the cell cycle. We show here that low levels of expression of SIC1 in Schizosaccharomyces pombe rescues all the phenotypes of cells lac...

Topics

Cell Cycle
Conserved Sequence
Cyclin-Dependent Kinase Inhibitor Proteins
Cyclin-Dependent Kinases
Cyclins
Fungal Proteins
Gene Deletion
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 9472012
DOI: 10.1242/jcs.111.6.843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9472012-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics