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Article

CLB5-dependent activation of late replication origins in S. cerevisiae.

Molecular cell - 1 Aug 1998

Donaldson A D, Raghuraman M K, Friedman K L, Cross F R, Brewer B J, Fangman W L

Abstract excerpt

Replication origins in chromosomes are activated at specific times during the S phase. We show that the B-type cyclins are required for proper execution of this temporal program. clb5 cells activate early origins but not late origins, explaining the previously described long clb5 S phase. Origin firing appears normal in cIb6 mutants. In clb5 clb6 double mutant cells, the late origin firing defect is suppressed,...

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PMID: 9734354
DOI: 10.1016/s1097-2765(00)80127-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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