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Article

Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.

Molecular and cellular biology - 1 Aug 2009

Kiang Lee, Heichinger Christian, Watt Stephen, Bähler Jürg, Nurse Paul

Abstract excerpt

To achieve faithful replication of the genome once in each cell cycle, reinitiation of S phase is prevented in G(2) and origins are restricted from refiring within S phase. We have investigated the block to rereplication during G(2) in fission yeast. The DNA synthesis that occurs when G(2)/M cyclin-dependent kinase (CDK) activity is depleted has been assumed to be repeated rounds of S phase without mitosis, but...

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Identifiers

PMID: 19487461
DOI: 10.1128/MCB.00185-09
PMCID: PMC2715816

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Source receipt: pubmed, retrieved 7 Sept 2026.

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