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Article

Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Sept 1995

Basco R D, Segal M D, Reed S I

Abstract excerpt

Cell cycle progression in the budding yeast Saccharomyces cerevisiae is controlled by the Cdc28 protein kinase, which is sequentially activated by different sets of cyclins. Previous genetic analysis has revealed that two B-type cyclins, Clb5 and Clb6, have a positive role in DNA replication. In...

Topics

Blotting, Northern
Cell Cycle Proteins
Cloning, Molecular
Cyclin B
Cyclins
Flow Cytometry
Fluorescent Antibody Technique
G1 Phase
G2 Phase
Hydroxyurea
Interphase
Models, Biological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Binding

Protein Kinases

RNA, Messenger

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7651421
DOI: 10.1128/MCB.15.9.5030
PMCID: PMC230750

Genes

CDC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7651421-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.PMID 7651421Read ↗

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.Semantic proximity Read ↗

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.Semantic proximity Read ↗

Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Semantic proximity Read ↗

Functional distinction between Cln1p and Cln2p cyclins in the control of the Saccharomyces cerevisiae mitotic cycle.Semantic proximity Read ↗

The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing.Semantic proximity Read ↗

Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.Semantic proximity Read ↗

CLB5: a novel B cyclin from budding yeast with a role in S phase.Semantic proximity Read ↗

Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression.Semantic proximity Read ↗

Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins.Semantic proximity Read ↗

Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.Semantic proximity Read ↗

G2 cyclins are required for the degradation of G1 cyclins in yeast.Semantic proximity Read ↗

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