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Article

Highly attenuated SIVmac142 is immunogenic but does not protect against SIVmac251 challenge.

AIDS research and human retroviruses - 1 Nov 1995

Denesvre C, Le Grand R, Boissin-Cans F, Chakrabarti L, Hurtrel B, Vaslin B, Dormont D, Sonigo P

Abstract excerpt

We report here the use of the highly attenuated SIVmac142 clone, unable to establish permanent infection of rhesus macaques, in a vaccine trial. Four rhesus macaques were immunized over a long time period with HUT-78 cells infected with wild-type SIVmac142 or, in order to reinforce the safety use of the vaccine, a deleted mutant with similar in vitro infectivity. The first two injections were done with living...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8573398
DOI: 10.1089/aid.1995.11.1397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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