Live attenuated HIV vaccines: pitfalls and prospects

doi:10.1097/00001432-200402000-00004

Article

Live attenuated HIV vaccines: pitfalls and prospects

12 Jan 2004

Abstract excerpt

PURPOSE OF REVIEW: When simian immunodeficiency virus (SIV) deleted in the nef gene caused no disease in macaques and provided protection against wild-type SIV challenge, hopes were high that the removal of nef would convert a pathogenic immunodeficiency virus into a live attenuated vaccine. We seek to highlight recent studies focused on several major issues regarding live attenuated AIDS viruses as vaccine...

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