Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Live attenuated HIV vaccines: pitfalls and prospects

12 Jan 2004

Abstract excerpt

PURPOSE OF REVIEW: When simian immunodeficiency virus (SIV) deleted in the nef gene caused no disease in macaques and provided protection against wild-type SIV challenge, hopes were high that the removal of nef would convert a pathogenic immunodeficiency virus into a live attenuated vaccine. We seek to highlight recent studies focused on several major issues regarding live attenuated AIDS viruses as vaccine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15090885
DOI: 10.1097/00001432-200402000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Live attenuated HIV vaccines: pitfalls and prospectsPMID 15090885Read ↗

Live attenuated AIDS viruses as vaccines: promise or peril?Semantic proximity Read ↗

Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus.Semantic proximity Read ↗

Live attenuated simian immunodeficiency virus vaccination confers superinfection resistance against macrophage-tropic and neurovirulent wild-type SIV challengeSemantic proximity Read ↗

Pathogenic Conversion of Live Attenuated Simian Immunodeficiency Virus Vaccines Is Associated with Expression of Truncated NefSemantic proximity Read ↗

Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost.Semantic proximity Read ↗

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the <i>nef</i> GeneSemantic proximity Read ↗

HIV vaccine design: insights from live attenuated SIV vaccinesSemantic proximity Read ↗

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.Semantic proximity Read ↗

Single-cycle immunodeficiency viruses provide strategies for uncoupling in vivo expression levels from viral replicative capacity and for mimicking live-attenuated SIV vaccines.Semantic proximity Read ↗

Cytotoxic T Lymphocyte–based Control of Simian Immunodeficiency Virus Replication in a Preclinical AIDS Vaccine TrialSemantic proximity Read ↗

An attenuated vaccine for AIDS?Semantic proximity Read ↗

Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.