Vaccine protection by a triple deletion mutant of simian immunodeficiency virus.

doi:10.1128/JVI.70.6.3724-3733.1996

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Article

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus.

Journal of virology - 1 Jun 1996

Wyand M S, Manson K H, Garcia-Moll M, Montefiori D, Desrosiers R C

Abstract excerpt

Twelve rhesus monkeys were vaccinated with SIVmac316 delta nef (lacking nef sequences), and 12 were vaccinated with SIVmac239 delta3 (lacking nef, vpr, and upstream sequences in U3). SIVmac316 and SIVmac239 differ by only eight amino acids in the envelope; these changes render SIVmac316 highly co...

Topics

Animals
Base Sequence
Macaca mulatta
Molecular Sequence Data
Mutation
SAIDS Vaccines
Simian Acquired Immunodeficiency Syndrome
Vaccination

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