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Article

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus.

Journal of virology - 1 Jun 1996

Wyand M S, Manson K H, Garcia-Moll M, Montefiori D, Desrosiers R C

Abstract excerpt

Twelve rhesus monkeys were vaccinated with SIVmac316 delta nef (lacking nef sequences), and 12 were vaccinated with SIVmac239 delta3 (lacking nef, vpr, and upstream sequences in U3). SIVmac316 and SIVmac239 differ by only eight amino acids in the envelope; these changes render SIVmac316 highly competent for replication in macrophages. Seventeen of the animals developed persistent infections with the vaccine...

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Identifiers

PMID: 8648707
DOI: 10.1128/JVI.70.6.3724-3733.1996
PMCID: PMC190248

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