Article
Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus.
The Journal of general virology - 1 Dec 1996
Stahl-Hennig C, Dittmer U, Nisslein T, Petry H, Jurkiewicz E, Fuchs D, Wachter H, Mätz-Rensing K, Kuhn E M, Kaup F J, Rud E W, Hunsmann G
Abstract excerpt
Convincing data on experimental vaccines against AIDS have been obtained in the simian immunodeficiency virus (SIV) macaque model by preinfection with a virus attenuated by a nef deletion. To investigate the efficacy of a nef deletion mutant of SIVmac32H called pC8 as a live-attenuated vaccine af...
Topics
- Animals
- Gene Deletion
- Gene Products, nef
- Lymph Nodes
- Macaca mulatta
- Phenotype
- SAIDS Vaccines
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- T-Lymphocytes, Helper-Inducer
- Vaccines, Attenuated