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Article

Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques.

Frontiers in immunology - 1 Jan 2024

Bimber Benjamin N, Sunshine Justine, McElfresh G W, Reed Jason S, Pathak Reese, Bateman Katherine B, Hughes Colette M, Gilbride Roxanne M, Ford Julia C, Morrow David, Lifson Jeffrey D, Sacha Jonah B, Hansen Scott G, Picker Louis J

Abstract excerpt

Simian immunodeficiency virus (SIV) vaccines based upon 68-1 Rhesus Cytomegalovirus (RhCMV) vectors show remarkable protection against pathogenic SIVmac239 challenge. Across multiple independent rhesus macaque (RM) challenge studies, nearly 60% of vaccinated RM show early, complete arrest of SIVmac239 replication after effective challenge, whereas the remainder show progressive infection similar to controls....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39170621
DOI: 10.3389/fimmu.2024.1444621
PMCID: PMC11336698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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