Article
Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251.
Virology - 5 Jan 2003
Nacsa Janos, Stanton Jennifer, Kunstman Kevin J, Tsai Wen Po, Watkins David I, Wolinsky Steven M, Franchini Genoveffa
Abstract excerpt
Structured treatment interruption (STI) of antiretroviral drugs has been proposed as an alternative approach for managing patients infected with HIV-1. While STI is thought to spare drug-related side effects and enhance the HIV-1-specific immune response, the long-lasting clinical benefit of this approach remains uncertain, particularly in patients with long-standing HIV-1 infection. Here, we investigated the...
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