Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge.

doi:10.1128/JVI.68.10.6578-6588.1994

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Article

Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge.

Journal of virology - 1 Oct 1994

Schlienger K, Montefiori D C, Mancini M, Rivière Y, Tiollais P, Michel M L

Abstract excerpt

The potential of the simian immunodeficiency virus (SIV) variable 2 (V2) domain as an effective region to boost SIV-neutralizing antibodies and to protect against live SIV challenge was tested in rhesus macaques. In this study, two rhesus macaques were primed with vaccinia virus recombinants expr...

Topics

Amino Acid Sequence
Animals
Antibodies, Viral
Antibody Formation
Antibody Specificity
Cytotoxicity, Immunologic
Enzyme-Linked Immunosorbent Assay
Epitopes
Genetic Variation
Macaca mulatta
Molecular Sequence Data
Neutralization Tests
Recombinant Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Vaccines, Synthetic

Viral Vaccines

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Identifiers

PMID: 7521918
DOI: 10.1128/JVI.68.10.6578-6588.1994
PMCID: PMC237078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7521918-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.