Article
Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques.
PloS one - 1 Jan 2011
Berry Neil, Ham Claire, Mee Edward T, Rose Nicola J, Mattiuzzo Giada, Jenkins Adrian, Page Mark, Elsley William, Robinson Mark, Smith Deborah, Ferguson Deborah, Towers Greg, Almond Neil, Stebbings Richard
Abstract excerpt
BACKGROUND: Live attenuated simian immunodeficiency virus (SIV) vaccines represent the most effective means of vaccinating macaques against pathogenic SIV challenge. However, thus far, protection has been demonstrated to be more effective against homologous than heterologous strains. Immune correlates of vaccine-induced protection have also been difficult to identify, particularly those measurable in the...
Topics
- Alleles
- Animals
- Antibodies, Neutralizing
- Antibodies, Viral
- Carrier Proteins
- DNA, Viral
- Haplotypes
- In Situ Hybridization
- Kinetics
- Lymphocyte Count