Article
Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.
The Journal of experimental medicine - 27 Oct 2008
Reynolds Matthew R, Weiler Andrea M, Weisgrau Kim L, Piaskowski Shari M, Furlott Jessica R, Weinfurter Jason T, Kaizu Masahiko, Soma Taeko, León Enrique J, MacNair Caitlin, Leaman Dan P, Zwick Michael B, Gostick Emma, Musani Solomon K, Price David A, Friedrich Thomas C, Rakasz Eva G, Wilson Nancy A, McDermott Adrian B, Boyle Rosanne, Allison David B, Burton Dennis R, Koff Wayne C, Watkins David I
Abstract excerpt
An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To address this issue in macaques, we administered a live-attenuated simian immunodeficiency virus (SIV) vaccine and challenged with a highly pathogenic heterologous isolate. Vaccinees reduced viral replication by approximately 2 logs between weeks 2-32 (P < or = 0.049) postchallenge. Remarkably, vaccinees expressing MHC-I...
Topics
- Animals
- Base Sequence
- CD8-Positive T-Lymphocytes
- DNA Primers
- Genetic Variation
- Macaca
- Molecular Sequence Data
- RNA, Viral
- Reverse Transcriptase Polymerase Chain Reaction