Article
High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19.
Oncogene - 18 Jan 1996
Douc-Rasy S, Barrois M, Fogel S, Ahomadegbe J C, Stéhelin D, Coll J, Riou G
Abstract excerpt
The few imprinted genes characterized so far include the insulin-like growth factor-2 gene (IGF2) coding for a foetal growth factor and the H19 gene whose normal function is unknown but which is likely to act as an RNA with an antitumour effect. IGF2 is expressed by the paternal allele and H19 by...
Topics
- Alleles
- Chromosome Deletion
- Female
- Genomic Imprinting
- Humans
- Insulin-Like Growth Factor II
- Methylation
- Muscle Proteins
- RNA, Long Noncoding
- RNA, Untranslated
- Uterine Cervical Neoplasms