Article
Loss of imprinting and overexpression of IGF2 gene in gastric adenocarcinoma.
Cancer letters - 25 Nov 1997
Wu M S, Wang H P, Lin C C, Sheu J C, Shun C T, Lee W J, Lin J T
Abstract excerpt
Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 gen...
Topics
- Adenocarcinoma
- Alleles
- Chromosomes, Human, Pair 11
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Imprinting, Psychological
- Insulin-Like Growth Factor II
- Male
- Muscle Proteins
- Polymorphism, Restriction Fragment Length
- RNA, Long Noncoding
- RNA, Neoplasm
- RNA, Untranslated
- Stomach Neoplasms