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Article

Loss of imprinting of igf2 in renal-cell carcinomas.

International journal of cancer - 30 Jan 1998

Oda H, Kume H, Shimizu Y, Inoue T, Ishikawa T

Abstract excerpt

Loss of imprinting (LOI) of the igf2 and h19 genes has been found not only in embryonal tumors but also in common adult cancers. To determine any possible role of genomic imprinting in the development of renal-cell carcinomas (RCCs), we examined the imprinting status of igf2 and h19 in a series of 22 such tumors, and studied its relation to their mRNA expression. Of 14 RCC specimens heterozygous for the ApaI...

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Identifiers

PMID: 9455791
DOI: 10.1002/(sici)1097-0215(19980130)75:3<343::aid-ijc3>3.0.co;2-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of imprinting of igf2 in renal-cell carcinomas.PMID 9455791Read ↗

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Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

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