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Article

Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Taniguchi T, Sullivan M J, Ogawa O, Reeve A E

Abstract excerpt

In most tissues IGF2 is expressed from the paternal allele while H19 is expressed from the maternal allele. We have previously shown that in some Wilms tumors the maternal IGF2 imprint is relaxed such that the gene is expressed biallelically. We have now investigated this subset of tumors further and found that biallelic expression of IGF2 was associated with undetectable or very low levels of H19 expression. The...

Topics

Alleles
DNA, Neoplasm
Female
Gene Expression
Genomic Imprinting
Humans
Insulin-Like Growth Factor II
Kidney Neoplasms
Male
Methylation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

RNA

Repetitive Sequences, Nucleic Acid

Wilms Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 7534414
DOI: 10.1073/pnas.92.6.2159
PMCID: PMC42443

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7534414-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.PMID 7534414Read ↗

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourSemantic proximity Read ↗

Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.Semantic proximity Read ↗

Epigenetic lesions at the H19 locus in Wilms' tumour patients.Semantic proximity Read ↗

Genomic imprinting and Wilms' tumor.Semantic proximity Read ↗

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19Semantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Semantic proximity Read ↗

Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor.Semantic proximity Read ↗

Role of genomic imprinting in Wilms' tumour and overgrowth disorders.Semantic proximity Read ↗

High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.Semantic proximity Read ↗

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