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Article

Non-conservative mutations are well tolerated in the globular region of yeast histone H4.

Journal of molecular biology - 26 Jan 1996

Agarwal S, Behe M J

Abstract excerpt

Yeast histone H4 has been mutagenized at several positions which participate in the globular core of the nucleosome. The native protein contains residues at those positions which are invariant or highly conserved over all known H4 sequences, whether from yeast, Tetrahymena or higher eukaryotes. Nonetheless the protein is tolerant of non-conservative mutations. At the level of cell function the mutant proteins...

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PMID: 8568885
DOI: 10.1006/jmbi.1996.0033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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