Article
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.
Molecular and cellular biology - 1 Sept 1990
Park E C, Szostak J W
Abstract excerpt
The N-terminal serine and four conserved lysine residues near the N-terminus of yeast histone H4 are acetylated. We found that a mutation that changed the fourth lysine to alanine resulted in specific derepression of the silent mating type locus HML, while mutations that altered the N-terminal serine or the first three lysines had only minor phenotypic effects. Our results support an active role for histone H4 in...
Topics
- Amino Acid Sequence
- Chromosomes, Fungal
- Genes, Fungal
- Histones
- Lysine
- Molecular Sequence Data
- Mutation
- Phenotype
- Plasmids
- Saccharomyces cerevisiae
- Serine
- Spores, Fungal