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Article

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

Molecular and cellular biology - 1 Sept 1990

Park E C, Szostak J W

Abstract excerpt

The N-terminal serine and four conserved lysine residues near the N-terminus of yeast histone H4 are acetylated. We found that a mutation that changed the fourth lysine to alanine resulted in specific derepression of the silent mating type locus HML, while mutations that altered the N-terminal serine or the first three lysines had only minor phenotypic effects. Our results support an active role for histone H4 in...

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Identifiers

PMID: 2117703
DOI: 10.1128/mcb.10.9.4932-4934.1990
PMCID: PMC361112

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