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Article

Effects of Sin- versions of histone H4 on yeast chromatin structure and function.

The EMBO journal - 15 Apr 1997

Wechser M A, Kladde M P, Alfieri J A, Peterson C L

Abstract excerpt

Previous studies have identified single amino acid changes within either histone H3 or H4 (Sin- versions) that allow transcription in the absence of the yeast SWI-SNF complex. The histone H4 mutants are competent for nucleosome assembly in vivo, and the residues that are altered appear to define a discrete domain on the surface of the histone octamer. We have analyzed the effects of the Sin- versions of histone...

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Source

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Identifiers

PMID: 9155034
DOI: 10.1093/emboj/16.8.2086
PMCID: PMC1169811

Genes

CYC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Effects of Sin- versions of histone H4 on yeast chromatin structure and function.PMID 9155034Read ↗

Sin mutations of histone H3: influence on nucleosome core structure and function.Semantic proximity Read ↗

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.Semantic proximity Read ↗

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin.Semantic proximity Read ↗

Sin mutations alter inherent nucleosome mobility.Semantic proximity Read ↗

Histone octamer function in vivo: mutations in the dimer-tetramer interfaces disrupt both gene activation and repression.Semantic proximity Read ↗

Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae.Semantic proximity Read ↗

The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.Semantic proximity Read ↗

A systematic mutational analysis of a histone H3 residue in budding yeast provides insights into chromatin dynamics.Semantic proximity Read ↗

A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.Semantic proximity Read ↗

Novel functional residues in the core domain of histone H2B regulate yeast gene expression and silencing and affect the response to DNA damage.Semantic proximity Read ↗

Histone H2A.Z acid patch residues required for deposition and function.Semantic proximity Read ↗

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