Simulations of SIN mutations and histone variants in human nucleosomes reveal altered protein-DNA and core histone interactions.

Abstract excerpt

Alterations in the stability of a nucleosome exert predominant influence on chromatin structure and eukaryotic gene expression. In an attempt to investigate the mononucleosome stability using computational approaches, we have simulated the structure of a human mononucleosome and have compared their energies under the influence of core mutations, tail substitutions, variant histones, and orthologs. We observe that...

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