Article
Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation.
Science (New York, N.Y.) - 16 Feb 1990
Megee P C, Morgan B A, Mittman B A, Smith M M
Abstract excerpt
The nucleosome is the fundamental unit of assembly of the chromosome and reversible modifications of the histones have been suggested to be important in many aspects of nucleosome function. The structure-function relations of the amino-terminal domain of yeast histone H4 were examined by the creation of directed point mutations. The four lysines subject to reversible acetylation were essential for histone...
Topics
- Acetylation
- Alleles
- Cell Cycle
- Chromosome Deletion
- Codon
- Glutamine
- Histones
- Lysine
- Mutation
- Plasmids
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae