Specification of multiple vertebral identities by ectopically expressed Hoxb-8.

doi:10.1002/aja.1002040103

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Article

Specification of multiple vertebral identities by ectopically expressed Hoxb-8.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 1995

Charité J, de Graaff W, Deschamps J

Abstract excerpt

We have recently generated Hoxb-8 gain-of-function mutant embryos, using a Hoxb-8 transgene driven by a retinoic acid receptor beta 2 promoter to extend the expression domain to more anterior regions of the embryo (Charité et al. [1994] Cell 78:589-601). Here we describe the phenotype in the axia...

Topics

Animals
Cervical Vertebrae
Gene Expression Regulation, Developmental
Genes, Homeobox
Mesoderm
Mice
Mice, Transgenic
Phenotype
Skull
Spine

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