Article
Specification of multiple vertebral identities by ectopically expressed Hoxb-8.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 1995
Charité J, de Graaff W, Deschamps J
Abstract excerpt
We have recently generated Hoxb-8 gain-of-function mutant embryos, using a Hoxb-8 transgene driven by a retinoic acid receptor beta 2 promoter to extend the expression domain to more anterior regions of the embryo (Charité et al. [1994] Cell 78:589-601). Here we describe the phenotype in the axial skeleton of transgenic embryos. The severity of the phenotype was variable, and cervical vertebrae and the base of...
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