Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.

doi:10.1038/370304a0

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Article

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.

Nature - 28 Jul 1994

Condie B G, Capecchi M R

Abstract excerpt

The Hox genes encode transcription factors which mediate the formation of the mammalian body plan along the anteroposterior and appendicular axes. Paralogous Hox genes within the separate linkage groups are closely related with respect to DNA sequence and expression, suggesting that they could ha...

Topics

Animals
Cervical Atlas
Cervical Vertebrae
Genes, Homeobox
Homozygote
Mice
Models, Genetic
Mutation

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