Article
Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column.
Mechanisms of development - 1 Jun 1994
Kostic D, Capecchi M R
Abstract excerpt
It is becoming clear that Hox genes, which encode transcription factors of the Antennapedia homeodomain family, are key players in establishing the body plan of mammalian embryos. They have already been implicated in the formation of the central nervous system, tissues derived from neural crest, the vertebral column and the limbs. In order to examine the roles of hoxa-4 and hoxa-6 during development, mice with...
Topics
- Alleles
- Animals
- Base Sequence
- Female
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Male
- Mice
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Spine