Article
Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function.
Proceedings of the National Academy of Sciences of the United States of America - 9 May 1995
Pollock R A, Sreenath T, Ngo L, Bieberich C J
Abstract excerpt
To investigate the functions of paralogous Hox genes, we compared the phenotypic consequences of altering the embryonic patterns of expression of Hoxb-8 and Hoxc-8 in transgenic mice. A comparison of the phenotypic consequences of altered expression of the two paralogs in the axial skeletons of newborns revealed an array of common transformations as well as morphological changes unique to each gene. Divergence of...
Topics
- Animals
- Biological Evolution
- Bone and Bones
- Gene Expression
- Genes, Homeobox
- Homeodomain Proteins
- Humans
- In Situ Hybridization
- Mice
- Mice, Transgenic
- Multigene Family