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Article

A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.

Developmental biology - 1 Jun 2000

Medina-Martínez O, Bradley A, Ramírez-Solis R

Abstract excerpt

Hox genes regulate axial regional specification during animal embryonic development and are grouped into four clusters. The mouse HoxB cluster contains 10 genes, Hoxb1 to Hoxb9 and Hoxb13, which are transcribed in the same direction. We have generated a mouse strain with a targeted 90-kb deletion within the HoxB cluster from Hoxb1 to Hoxb9. Surprisingly, heterozygous mice show no detectable abnormalities....

Topics

Animals
Cranial Nerves
Gene Deletion
Genes, Homeobox
Mice
Mice, Mutant Strains
Multigene Family
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10885747
DOI: 10.1006/dbio.2000.9683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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