Article
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.
Development (Cambridge, England) - 1 Nov 1993
Condie B G, Capecchi M R
Abstract excerpt
Gene targeting in embryo-derived stem (ES) cells was used to generate mice with a disruption in the homeobox-containing gene Hoxd-3 (Hox-4.1). Mice homozygous for this mutation show a radically remodeled craniocervical joint. The anterior arch of the atlas is transformed to an extension of the ba...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cervical Vertebrae
- DNA Primers
- DNA-Binding Proteins
- Gene Deletion
- Gene Expression
- Genes, Homeobox
- Genotype
- Homeodomain Proteins
- In Situ Hybridization
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Stem Cells