Article
The use of IgH fingerprinting and ASO-dependent PCR for the investigation of residual disease (MRD) in ALL.
British journal of haematology - 1 Jan 1996
Chim J C, Coyle L A, Yaxley J C, Cole-Sinclair M F, Cannell P K, Hoffbrand V A, Foroni L
Abstract excerpt
In acute lymphoblastic leukaemia (ALL), investigation of minimal residual disease by conventional morphology and immunology fails to detect levels of residual disease of < 1 leukaemic in 10-100 normal cells. The use of polymerase chain reaction (PCR) to exploit the diversity of the complementarity determining region (CDR) and immunoglobulin variable heavy chain (VH) family specific usage has greatly improved the...
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