Article
Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia.
Annals of hematology - 1 Sept 2009
Schwarz Arne Kristian, Stanulla Martin, Cario Gunnar, Flohr Thomas, Sutton Rosemary, Möricke Anja, Anker Philippe, Stroun Maurice, Welte Karl, Bartram Claus R, Schrappe Martin, Schrauder André
Abstract excerpt
The analysis of total plasma DNA and the monitoring of leukemic clone-specific immunoglobulin and/or T-cell receptor gene rearrangements for the evaluation of minimal residual disease (MRD) in the plasma may be useful tools for prognostic purposes or for early detection of subclinical disease recurrence in children with acute lymphoblastic leukemia (ALL). The aim of this paper is to establish reference ranges for...
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