Article
Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR.
British journal of haematology - 1 Mar 2005
Kerst Gunter, Kreyenberg Hermann, Roth Carmen, Well Catrin, Dietz Klaus, Coustan-Smith Elaine, Campana Dario, Koscielniak Ewa, Niemeyer Charlotte, Schlegel Paul G, Müller Ingo, Niethammer Dietrich, Bader Peter
Abstract excerpt
Minimal (i.e. submicroscopic) residual disease (MRD) predicts outcome in childhood acute lymphoblastic leukaemia (ALL). To be used clinically, MRD assays must be reliable and accurate. Two well-established techniques, flow cytometry (FC) and polymerase chain reaction (PCR), can detect leukaemic cells with a sensitivity of 0.01% (10(-4)). We analysed diagnostic samples of 45 ALL-patients (37 B-lineage ALL, eight...
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