Improved detection of minimal residual leukemia through modifications of polymerase chain reaction analyses based on clonospecific T cell receptor junctions.

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Article

Improved detection of minimal residual leukemia through modifications of polymerase chain reaction analyses based on clonospecific T cell receptor junctions.

Leukemia - 1 Feb 1995

Seriu T, Hansen-Hagge T E, Erz D H, Bartram C R

Abstract excerpt

Polymerase chain reaction (PCR) techniques utilizing clonospecific T cell receptor (TCR) gamma or delta junctional regions constitute broadly applicable strategies to study the clinical relevance of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) patients. For the majority of cases current PCR protocols allow the reliable detection of one neoplastic cell among 10(4) to 10(6) normal...

Topics

Alleles
Base Sequence
Biotin
Child
Clone Cells
DNA Primers
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Neoplasm, Residual

Polymerase Chain Reaction

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Prospective Studies

Receptors, Antigen, T-Cell, gamma-delta

Sensitivity and Specificity

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 7869770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7869770-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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