Article
Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response.
Leukemia - 1 Oct 1997
Foroni L, Coyle L A, Papaioannou M, Yaxley J C, Sinclair M F, Chim J S, Cannell P, Secker-Walker L M, Mehta A B, Prentice H G, Hoffbrand A V
Abstract excerpt
Immunoglobulin heavy chain gene (IgH gene) rearrangements are found in the majority of patients with B lineage acute lymphoblastic leukaemia (ALL). Two hundred and three bone marrow samples from 54 patients (33 adults and 21 children) were analysed by PCR within specific time-points after diagnosis (ie 1, 2-3, 4-6 and 7-12 months) using FR1 and JH primers (fingerprinting with a sensitivity > or =1:5 x 10[3])....
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