Article
Flow cytometry and allele-specific oligonucleotide PCR are equally effective in detection of minimal residual disease in ALL.
Leukemia - 1 May 2001
Malec M, Björklund E, Söderhäll S, Mazur J, Sjögren A M, Pisa P, Björkholm M, Porwit-MacDonald A
Abstract excerpt
The analysis of minimal residual disease (MRD) has assumed a growing role in the follow-up of patients with acute lymphoblastic leukemia (ALL). We have applied multiparameter flow cytometry (FC) with 'live-gate' analysis and allele-specific oligonucleotide (ASO)-PCR detecting leukemia-specific T cell receptor gamma and delta gene rearrangements for MRD follow-up in 30 ALL patients. The comparison of results...
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