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Article

Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance.

Frontiers in immunology - 1 Jan 2026

Preedia Babu E, Haga Yuki, Ray Ranjit

Abstract excerpt

Background: Hepatitis C virus (HCV) infection poses a major global risk for chronic liver disease, underscoring the critical need for prevention. Our previous studies demonstrated that HCV-modified soluble E1/E2F442NYT envelope glycoproteins delivered from an mRNA-lipid nanoparticle (LNP) vaccine platform induce immune responses in vitro in human cells and in vivo in immunized mice. These findings prompted us to...

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Identifiers

PMID: 41939904
DOI: 10.3389/fimmu.2026.1745299
PMCID: PMC13047202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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